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Cleaning and disinfection systems for medical instruments. The present invention relates to bacteria jabon liquido concentrado disinfection systems and cleaning, preferably without aldehydes with a surfactant content, anticorrosive agents and other additives, which enhance cleaning as well as their bacteria jabon liquido concentrado for cleaning and simultaneous or subsequent disinfection of medical instruments, in particular for cleaning and simultaneous or subsequent disinfection of flexible endoscopes.
As disinfectant substance that is suitable for disinfection, that is, to combat pathogenic microorganisms e. Sanitizers bacteria jabon liquido concentrado in a localized manner, for example, for disinfection of wounds, will be referred antiseptics. Disinfecting agents are defined as substances or mixtures of substances, in use on objects or surfaces, change their state bacteria jabon liquido concentrado that they can undergo no bacteria jabon liquido concentrado infection.
Action must be bactericidal, fungicidal, virucidal and sporicidal global concept microbicide. Un efecto en el sentido de una bacteriostasis es insuficiente para el agente desinfectante. An effect in the sense of bacteriostasis is insufficient for the disinfectant. Depending on the purpose of application, the disinfectants are divided into agents for disinfecting clothing, surfaces, instruments, hands and skin and stool and sputum. As it is understood that scavenger acts as disinfectant cleaning agent and preservative.
Given the multiple requirements required of a disinfectant, such as a wide spectrum of action, a short-time action, skin tolerance, low toxicity, tolerance of the material, some types of substances are used only: In addition to the microbicidal substances mentioned there are a number of substances and preservatives diphenyl ether, carbanilides, acetanilides aromatic acids and their salts for a specific application in the market, which are to be considered in a broader sense of disinfectants.
There is no single action of disinfectants. Endoscopes are instruments shaped pipe or conduit, used for research or examination of the body cavities and hollow organs. They are equipped with an optical system consisting of an objective and an eyepiece, a lighting device and a washing and aspiration devices and channels to introduce special instruments. Flexible endoscopes which have been termed fibroendoscopios are provided with a light conductor of glass fiber, consisting of a thick bundle of fine individual fibers and thus flexible.
Thanks to the flexibility of the glass fibers and the image light may be transmitted through virtually any angle. In addition to the fiber bundle and the Bowden cable it has been located channels for the movement of the tips for rinsing with water and air as well as a channel of generally greater biopsy and suction channels simultaneously. Endoscopy may be performed alone presentations, for example for sampling of tissue, but also in combination with other methods, such as ultrasound diagnosis Endosonography or X-ray diagnosis are usual, for example, radiocontrast gallbladder and bile duct and pancreatic system.
For this, for example, within an endoscopic retrograde cholangiography of ERC or a cholangiopancreaticography ERCP it has been applied endoscopic retrograde dye radiological radiological imaging in the duct system to be examined.
The current technique known liquid disinfectants for cleaning and disinfecting flexible endoscopes and medical devices containing in addition to surfactants and disinfecting substances, organic solvents, acids or bases.
En general, los compuestos mencionados tienen algunos inconvenientes: In general, such compounds have some drawbacks: Solvents, acids and bases are suitable for their activity certainly for purification, but have the disadvantage that they are too aggressive for the sensitive material and medical devices or endoscopes may be damaged.
Disinfectant liquids of the art are quite effective to remove traces of blood and secretion as well as to dissolve fat and other components containing hydrocarbons. They are not meant to completely remove traces of radiocontrast bacteria jabon liquido concentrado.
The object of the invention to develop a disinfectant and scavenger, free aldehydes, liquid system which does not have the drawbacks of the prior art, which show a good cleaning power and a simultaneous or subsequent disinfection with a tolerance of the material at the same high and with a minimum use exhibit good activity against Gram-positive and -negative bacteria, fungi, viruses, and mycobacteria concentration time.
Sorprendentemente se ha observado que todos estos cometidos se resuelven mediante un sistema desinfectante y depurador, que se ha configurado de manera que engloba Surprisingly it has been found that all these tasks bacteria jabon liquido concentrado solved by a disinfectant and cleaning system, which is configured so that encompasses. B un segundo preparado, que en un soporte apropiado contiene B a second preparation, which in a suitable carrier contains.
It has especially surprised that disinfectants and purifying systems according to the invention clean better than those prepared in the prior art and that by this improved cleaning and simultaneous or subsequent disinfecting flexible endoscopes tested were able to significantly reduce the microbiological problems of the prior art.
According to the invention are preferred quaternary ammonium compounds chosen from the group of benzalkonium chloride, didecyldimethylammonium chloride, dioctyldimethylammonium chloride, dimetildeciloxetilamonio propionate, cetrimonium bromide, cetylpyridinium chloride hexadecylpyridinium chloride. According to the invention are preferable alkylamines selected from the group of fatty amine derivatives, the laurilpropilendiamina and dodecilbispropilentriamina, particularly dodecilbispropilentriamina.
According to the invention, preferred amino acids are for example glutamic acid, which is characterized by the following structural formula: It is preferable that the total amount of amino acid one or more compounds is chosen between 0.
According to the invention are preferably used nonionic surfactants, particularly those selected from the group of alkyl ethoxylates, the alkyl group bacteria jabon liquido concentrado a saturated or unsaturated alkyl of straight or branched chain containing 8 to 18, preferably 12 to 14 carbon atoms. For groups branched alkyl these contain per molecule 2 to 15, in particular 5 to 9, especially 7 units of ethylene, and in the case of alkyl groups of straight-chain 2 to 15, especially 8 to 14, in particular 12 units of ethylene oxide per molecule.
It is preferred that the total amount of nonionic surfactant one or more compounds is chosen in the range from 1. A disinfectant and cleansing system according to the invention thus configured is performed as a "Set" in which the preparations A and B are separated from each other and are stored in separate containers.
Preparations A can be set in this case so that the or nonionic surfactants are chosen from the group of alkyl ethoxylates, the alkyl group is a saturated or unsaturated, branched or straight chain, withpreferably 12 to 14 carbon atoms.
In the case of alkyl groups branched chain contain per molecule 2 to 15, bacteria jabon liquido concentrado particular 5 to 9, especially 7 units ethylene oxide and in the case of alkyl groups of straight-chainin particularespecially 12 units of ethylene oxide per molecule. Bacteria jabon liquido concentrado is preferred that the total amount of nonionic surfactant one or more compounds is chosen from the range from 1. Preparations A may be in the form of liquid concentrates and for example be packaged in bags dosing, so that a fresh solution can be employed.
It is preferred that the pH of the concentrate is between 7 and The liquid concentrates are preferably diluted with water to a use solution. The use solution preferably has a pH between 7 and 10, for optimal preservation of sensitive material. It is preferable to perform dilution so that the content of each of the substances in the use solution is the following: Preparations A may further contain conventional corrosion inhibitors, such as benzotriazole, particularly in use with metal surfaces, particularly steel unrefined or materials based on non-ferrous metal alloys, may contact.
It is preferable that the content of one or more corrosion inhibitors is between 0. The amounts to be used in this type of bacteria jabon liquido concentrado materials and perfumes can be readily ascertained by a simple test if depend on the type of product.
Preparations B containing one or more active substances in a suitable support microbicides. They can be in the form of solid concentrates, for example, tablets, powders, granules and packed into bags, so that a solution of freshly prepared application could be used.
They can also take the form of solutions or suspensions in non-aqueous solvents. Furthermore preparations B may contain conventional corrosion inhibitors, such as benzotriazole, in particular can contact metallic surfaces, especially steel unrefined or non-ferrous material alloys. These, in most cases, do not have a disinfectant, preservative or antiseptic, but serve for aesthetic purposes, storage and handling.
However, it is possible to employ such components develop an action preservative and simultaneously take care of a certain color or aroma. The amounts to be used respectively support such substances and perfumes can be readily ascertained by a simple test, depending on the type of product. The following examples are no example of the role solution.
Todas las cantidades, concentraciones y porcentajes se bacteria jabon liquido concentrado, mientras no se indique lo contrario, al peso ya la cantidad total o al peso total del preparado.
All amounts, levels and percentages are, unless the contrary is not provided, the weight and the total amount or the total weight of the preparation. System cleaning and disinfecting, to be configured to have: A a first preparation in the form of a liquid detergent for medical instruments, containing: The most important group of active substances are aldehydes formaldehyde, glyoxal, glutaraldehyde. They possess a broad spectrum of action including viral activity and sporicidal action in formaldehyde and glutaraldehyde.
They can lead to awareness, in particular, skin and respiratory organs. Its use has clearly reduced by toxicological issues. The aldehyde-based disinfectants also have an unpleasant, pungent odor and very characteristic. Phenolic derivatives possess good bactericidal action, but they are not sporicidal. As opposed to most other disinfectants have the advantage that they are little influenced by dirt. They are therefore suitable for disinfection of feces.
Their typical representatives are 2-bifenilol and p-chloro-m-cresol 4-chloromethylphenol. Generally they have some drawbacks from toxicologically bacteria jabon liquido concentrado ecologically.
Of the halogens, chlorine and iodine have a certain importance as disinfectants. Chlorine is known for water treatment and disinfection of swimming pools and therefore its unpleasant properties bacteria jabon liquido concentrado odor and corrosivity. Despite an outstanding action against bacteria, fungi, spores and viruses containing chlorine disinfectants they are not widespread in the human field for the aforementioned reasons and strong chlorine consumption organic substances. Conversely, hypochlorites, chlorinated lime and the chloroisocyanuric acid are widely used as disinfectants technicians.
Iodine tincture is used as an antiseptic in the field of medicine. Disinfectants based active oxygen for example, hydrogen peroxide, peroxyacetic acid have become very bacteria jabon liquido concentrado lately. Los compuestos cuaternarios de amonio, tensoactivos de cationes jabones invertidos y los anfotensoactivos pertenecen a la clase de bacteria jabon liquido concentrado tensoactivos.
Quaternary ammonium compounds, surfactants bacteria jabon liquido concentrado cations inverted soaps and anfotensoactivos belong to the class bacteria jabon liquido concentrado surfactants. Are characterized by a very good tolerance of the material, have markedly improved, less skin sensitization without practically odorless toxicological profile.
Its spectrum of action is, however, quite limited and have very poor activity against gram-negative bacteria and mycobacteria. Bacteria jabon liquido concentrado este grupo pertenecen, por ejemplo, el cloruro de benzalconio, el bromuro de cetrimonio, cloruro de cetilpiridinio cloruro de hexadecilpiridiniocloruro de didecildimetilamonio y otros.
This group includes, for example, benzalkonium chloride, cetrimonium bromide, cetylpyridinium chloride hexadecylpyridinium chloridedidecyldimethylammonium chloride and others. The quaternary ammonium compounds are organic ammonium compounds with quaternary nitrogen atoms.
The quaternary ammonium compounds having a hydrophobic alkyl radical are biocides. The quaternary ammonium compounds are produced by converting the tertiary amine with alkylating means, such as methyl chloride, benzyl chloride, dimethyl sulfate, dodecyl bromide, and even ethylene oxide. Dependiendo de la amina terciaria empleada se diferencian tres bacteria jabon liquido concentrado Depending on the tertiary amine used three groups differ: The alkylation of tertiary amines with long alkyl radical and two methyl groups is particularly simple, and even the quaternization of tertiary amines with two long radicals and a methyl group can be performed using methyl chloride under mild conditions.
Las aminas, que disponen de tres radicales alquilo largos bacteria jabon liquido concentrado de radicales alquilo hidroxisustituidos, son poco reactivas y se cuaternizan preferiblemente con bacteria jabon liquido concentrado de dimetilo. Amines which have three long radical or alkyl hydroxy substituted alkyl radicals are unreactive and are preferably quaternized with dimethyl sulfate.
Other disinfectants are based on the use of alkylamines. Among the most important representatives of this group are those derived from fatty amines, such as the laurilpropilendiamina "cocospropilendiamina" and dodecilbispropilentriamina. Alkylamines have the same advantages over the aldehydes that quaternary ammonium compounds have a surprising ability to have better disinfection and action spectrum compared to quaternary ammonium compounds, against Gram-negative bacteria.
However, they can cause damage to certain plastic and can not be used in all instruments. System for cleaning and disinfecting, to be configured to have. B un segundo preparado, que en un soporte apropiado contiene B a second preparation, which contains an appropriate support. System cleaning and disinfection according to claim 1, characterized in that the alkylamines are selected from the group dodecilbispropilentriamina, laurilpropilendiamina.
System cleaning and disinfection according to claim 1, characterized in that the quaternary ammonium compounds are selected from the group of benzalkonium chloride, didecyldimethylammonium chloride, dioctyldimethylammonium chloride, dimetildeciloxetilamonio propionate, cetrimonium bromide, cetylpyridinium chloride hexadecylpyridinium chloride.
